Effects of Mycophenolate Mofetil and Rapamycin on Peritoneal Fibrosis in an Experimental Model of Peritoneal Dialysis Deneysel Periton Diyaliz Modelinde Mikofenolat Mofetil ve Rapamisinin Periton Fibrozisine Etkileri
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چکیده
MATERIAL and METHODS: A total of 60 male Albino rats (Wistar strain) were equally divided into four groups as follows: Mycophenolate mofetil group (MMFG), rapamycin group (RAPG) and no-treatment group (NTG) receiving 15 mL 3.86% glucose solution, and control group (CG) receiving daily intraperitoneal injection of 15 mL normal saline. Mycophenolate mofetil and rapamycin were administered orally via daily gastric gavage in MMFG and RAPG. We conducted one-hour peritoneal equilibration tests at 8 weeks, measuring ultrafiltration, serum and dialysate growth factors and cytokines. Peritoneal membrane morphology was examined under the light microscope.
منابع مشابه
Successful treatment of encapsulating peritoneal sclerosis with immunosuppressive therapy.
Encapsulating peritoneal sclerosis is a rare, but potentially lethal, complication of peritoneal dialysis. Treatment of patients with encapsulating peritoneal sclerosis is controversial. Conservative treatment carries a poor outcome, and immunosuppressive drugs are now used frequently. Most commonly, these immunosuppressive regimens include steroids with or without azathioprine or cyclosporine....
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